神经胶质细胞

出版时间：2010-8  出版社：科学出版社  作者：斯奎尔 编  页数：544  
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内容概要

《神经科学百科全书》原书篇幅巨大，为所有神经科学百科全书之首。由来自世界各地的2400多位专家撰稿人合力打造，覆盖了神经科学全部主要领域。每个词条在收入书中之前均经过顾问委员会的同行评议，词条中均含有词汇表、引言、参考文献和丰富的交叉参考内容。    主编为著名神经科学家、美国神经科学学会前主席LarryR.Squire。内容平易，本科生即可读懂。深度和广度独一无二，足可满足专家学者的需要。导读版精选原书中的部分主题，按内容重新编排，更适合国内读者购买和阅读。

作者简介

编者：（美国）斯奎尔（Larry R.Squire）

书籍目录

神经胶质细胞：起源、多样性与功能  Activity-Dependent Metabolism in Glia and Neurons  Astrocyte: Calcium Signaling  Astrocyte: Identification Methods  Astrocyte: Neurotransmitter and Hormone Receptors  Astrocyte: Response to Injury  Axon Guidance by Glia  Axonal Regeneration: Role of the Extracellular Matrix and the Glial Scar  Bergmann Glial Cells  Calcium Homeostasis in Glia  Calcium Waves in Glia  Cytokine Receptors in Glia  Enteric Nervous System: Glial Cells and Interstitial Cells of Cajal  Ependymal Cells  Gap Junctions and Hemichannels in Glia  Glia and Stroke  Glia Control of Blood Flow  Glial Cells: Astrocytes and Oligodendrocytes during Normal Brain Aging.  Glial Cells: Invertebrate  Glial Cells: Microglia during Normal Brain Aging  Glial Cells: T Cell Interactions  Glial Energy Metabolism: A NMR Spectroscopy Perspective  Glial Energy Metabolism: Overview  Glial Glutamate and GABA Metabolism  Glial Glutamate Transporters  Glial Glutamate Transporters: Electrophysiology  Glial Glycogen Metabolism  Glial Growth Factors  Glial Influence on Synaptic Transmission  Glial Ion Homeostasis: A Fluorescence Microscopy Approach  Glial Plasticity and Neuroendocrine Regulation  Glial Responses to Injury  Glial Responses to Virus Infection  Giial Steroid Metabolism  Glioma  Intermediate Filaments  Ionic Channels in Glia  Macroglial Lineages  Microglia Identification Methods  Microglia Properties  Microglial Response to Injury  Myelin: Molecular Architecture of CNS and PNS Myelin Sheath  Neuron-Glia pH Regulation  Neuron-Glia Coupling in Glutathione Metabolism  Neuropeptides and Receptors in Glia  Neurotransmitter and Hormone Receptors on Oligodendrocytes and Schwann Cells  Neurotransmitter Release from Astrocytes  Oligodendrocyte and Schwann Cell Identification Methods  Oligodendrocyte Morphology  Oligodendrocyte Specification  Potassium Homeostasis in Glia  Radial Glial Cells: Brain Functions  Retinal Glia  Schwann Cell Development  Schwann Cell Morphology  Schwann Cells and Axon Relationship  Schwann Cells and Plasticity of the Neuromuscular Junction  Transplantation of Myelin Forming Cells  Transporter Proteins in Neurons and Glia能量与离子的细胞内调控  Activity-Dependent Regulation of Glucose Transporters  Brain Glucose Metabolism:Age, Alzheimer's Disease, and ApoE Allele Effects  Brain Injury: Magnetic Resonance Studies of Metabolic Aspects  Brain Na,K-ATPase  Cell-Cell Communication Through the Extracellular Space  Intracellular Calcium and Neuronal Death  Mitochondrial Dysfunction in Nervous System Injury  Monocarboxylate Transporters  Regulation of Cell Volume in Neural Cells原书词条中英对照表

章节摘录

插图：Approximately 10 years ago, transgenic mice weregenerated in which the green fluorescent proteinsS65T-GFP or later EGFP were used to label astro-cytes. The unique advantage of fluorescent proteinsis buried in their structure, in which the fluorophor isspontaneously generated from three residues of thepolypeptide chain （by cyclization and oxidation）. Noexogenous cofactors are needed as labeling dyes.GFAP-GFP transgenic mice revolutionized the identi-fication of astrocytes in brain tissue. For the first time,it was possible to unequivocally identify astrocytes inall brain regions without prior immunohistochemicallabeling, which normally requires tissue fixation. Liveastrocytes could be analyzed in acutely isolated brainslices or even in vivo. Via fluorescence-activatedcell sorting, fluorescent astrocytes could be isolatedund subsequently analyzed in cell culture. Using thisapproach, the neurogenic potential of embryonic radialglia cells was revealed. In addition, acutely isolatedtissue slices isolated from brain regions such as thebrain stem or hippocampus served for the analysisof the dynamic interaction of astroglial processeswith neighboring active synaptic terminals. Time-lapserecordings demonstrated highly motile lameUipodiaand filopodia emanating from major process branches.This work strengthened the view of astrocytes as regu-lators of neuronal transmission. However, astrocytesdo not just modulate neuronal function. In vivo, thepivotal role of astroglial endfeet associated with neigh-boring capillaries could be demonstrated.  Transgenic labeling with the human GFAP pro-moter has been very helpful in identifying cells withastroglial properties in other species such as thezebra fish. Another important approach to labelastrocytes uses viral infections. Baculo-, lenti-,adeno-, and adeno-associated viruses carrying GFAPpromoter elements have been used to deliver genes ofinterest into astrocytes. Depending on brain regionand tropism of the viral substrain, even preferentialinfection of astrocytes can be achieved.

编辑推荐

《神经科学百科全书》由科学出版社出版。

用户评论 (总计3条)

•   书很专业，值得一看
•   书还可以啦，就是希望能是彩印版的更好。不过这个价格还是很划算的。
•   国内不可能买到这么好的书了