细胞内转运与细胞骨架

出版时间：2010-8  出版社：科学出版社  作者：斯奎尔 编  页数：674  

前言

什么是百科全书？这一名词来自于两个希腊单词：enkuklios（意思是循环的）和paideia（意思是教育）。在16世纪早期，拉丁手稿的抄写者们将这两个单词合而为一，其在英语中演化为一个单词，意思是具有广泛指导意义的工具书（The American Heritage Dictionary，2000，Boston：Houghton Mifflin，p.589）。从其来源可见，其希腊文原词中蕴含着以探索、综合的方式努力获取知识的含义。无论是拉丁文还是英文，该单词泛指涵盖广泛领域知识的工具书。希腊文中强调的以创造性手段获取知识，在神经科学领域尤其适用。神经科学本身就是一个非常新的名词。Francis Schmitt在本书第一版的前言中指出，本书的编写过程就是将不同领域的科学家们聚集在一起，冲击大脑研究中最顽固的难题。他推动建立了神经科学研究项目（Neuroscience Research Program，简称NRP）。早期的NRP成员包括一些学术巨匠，如因关于光合作用的研究获得诺贝尔奖的Melvin Calvin、诺贝尔奖获得者物理化学家Manfred Eigen、生物化学家Albert Lehninger，和当时正在努力破解基因编码的年轻分子生物学家Marshall Nirenberg。

内容概要

《神经科学百科全书》原书篇幅巨大，为所有神经科学百科全书之首。由来自世界各地的2400多位专家撰稿人合力打造，覆盖了神经科学全部主要领域。书中每个词条在收入书中之前均经过顾问委员会的同行评议，词条中均含有词汇表、引言、参考文献和丰富的交叉参考内容。

作者简介

编者：（美国）斯奎尔（Larry.R.Squire）

书籍目录

细胞为信号级联与第二信使  Calcium-Calmodulin Kinase Ⅱ (CaMKII) in Learning and Memory  Cyclic AMP (cAMP) Role in Learning and Memory  Eph Receptor Signaling and Spine Morphology  MAP Kinase Signaling in Learning and Memory  Neural Crest Cell Diversification and Specification: ErbB Role  Notch Pathway: Lateral Inhibition  Notch Signal Transduction: Molecular and Cellular Mechanisms  Retinoic Acid Signaling and Neural Patterning  Sonic Hedgehog and Neural Patterning  Synaptic Plasticity: Diacylglycerol Signalling Role  Wnt Pathway and Neural Patterning细胞内转运与细胞骨架  Actin Cytoskeleton in Growth Cones, Nerve Terminals, and Dendritic Spines  AMPA Receptor Cell Biology/Trafficking  Axonal and Dendritic Identity and Structure: Control of  Axonal and Dendritic Transport by Dyneins and Kinesins in Neurons  Axonal mRNA Transport and Functions  Axonal Transport and ALS  Axonal Transport and Alzheimer's Disease  Axonal Transport and Huntington's Disease  Axonal Transport and Neurodegenerative Diseases  Axonal Transport Disorders  Axonal Transport Tracers  Cytoskeletal Interactions in the Neuron  Cytoskeleton in Plasticity  Dendrites: Localized Translation  Dendritic RNA Transport: Dynamic Spatio-Temporal Control of Neuronal Gene Expression  Dystrophin, Associated Proteins, and Muscular Dystrophy  Intermediate Filaments  LIM Kinase and Actin Regulation of Spines  Lysosome and Endosome Organization and Transport in Neurons  Microtubule Associated Proteins in Neurons  Microtubules: Organization and Function in Neurons  Mitochondrial Organization and Transport in Neurons  Myosin Transport and Neuronal Function  Neurofilaments: Organization and Function in Neurons  Neuronal Motility and Structure: MARK and GSK Pathways  NMDA Receptors, Cell Biology and Trafficking  Nuclear Movements in Neurons  Peroxisomes: Organization and Transport in Neurons  Prion Transport  Proteasome Role in Neurodegeneration  Protein Folding and the Role of Chaperone Proteins in Neurodegenerative Disease  Retrograde Neurotrophic Signaling  Slow Axonal Transport  Spectrin: Organization and Function in Neurons  Transport Dependent Damage Signaling  Vesicular Sorting to Axons and Dendrites分泌与囊泡循环  Active Zone  Botulinum and Tetanus Toxins  Calcium Channel Subtypes Involved in Neurotransmitter Release  Calcium Channels and SNARE Proteins  CIRL/Latrophilins  Clathrin and Clathrin-Adaptors  Complexins  Cysteine-String Proteins (CSPs)  Dynamin  Endocytosis: Kiss and Run  Exocytosis: cae+-Sensitivity  Fusion Pore  Large Dense Core Vesicles (LDCVs)  Latrotoxin  Liprins, ELKS, and RIM-BP Proteins  Lysosomal System  Munc13 and Associated Molecules  Munc18  Neurexins  Neuroligins  Neurosecretion (Regulated Exocytosis in Neuroendocrine Cells)  Neurotransmitter Release from Astrocytes  Neurotransmitter Release: Synchronous and Asynchronous  NSF and SNAPs  Optical Monitoring of Exo- and Endocytosis  PHR (Pam/Highwire/RPM-1)  Piccolo and Bassoon  Presynaptic Receptor Signaling  Rab3  Rab3A Interacting Molecules (RIMs)  RNA Granules: Functions within Presynaptic Terminals and Postsynaptic Spines  SNAREs  Synapsins  Synaptic Plasticity: Short-Term Mechanisms  Synaptic Vesicle Protein-2 (SV2)  Synaptic Vesicles  Synaptojanin  Synaptotagmins  SynCAMs  Synucleins  Vesicle Pools  Vesicular Neurotransmitter Transporters  Voltage-Gated Calcium Channels原书词条中英对照表

章节摘录

插图：Though the E（spl） enhancerincludes high-affinity proneural binding sites, highlevels of proneural protein expression in the prospec-tive SOP cannot independently drive E（spl） geneexpression because in the absence of NotchIC, Su（H）functions as part of a repressor complex that ensuresgenes in the E（spl） complex are not expressed. Insurrounding non-SOP cells of the PNC, whereNotch is activated by the SOP cell, NotchIc makesSu（H） function as an activator to drive E（spl） geneexpression.The Complementary Role of Bearded Family Genesin the E（Spl） ComplexThe E（spl） complex also includes non-bHLH genes ofthe Bearded （Brd） family. Their expression is alsoregulated by Notch activation; however, unlike theE（spl） bHLH genes, they do not inhibit proneuralgene expression. Instead, they interfere with Deltafunction by inhibiting Neuralized mediated endocy-tosis of Delta, a step that is essential for effectiveactivation of Notch in the neighboring cell （Figure 2）.toestablishment of a central biasing mechanism during

用户评论 (总计1条)

•   经典书，需要的懂的。