出版时间:2007-7 出版社:高教分社 作者:科他萨 页数:264
内容概要
国外生命科学优秀教材。
书籍目录
PrefaceListofAbbreviationsIntroductionIntroductoryOutlinesMetabolicandCellularEngineeringintheContextofBioprocessEngineeringToolsforMetabolicandCellularEngineeringEngineeringCellsforSpecificBiotransformationsMetabolicAreasthatHaveBeenSubjectedtoMCEFromDNASequencetoBiologicalFunctionTemporalandSpatialScalinginCellularProcessesScalinginMicrobialandBiochemicalSystemsViewsoftheCellTransductionandIntracellularSignallingSelf-organizedEmergentPhenomenaHomeodynamicsandCoherenceMatterandEnergyBalancesMassBalanceEnergyBalanceCellGrowthandMetaboliteProduction.BasicConceptsMicrobialGrowthunderSteadyandBalancedConditionsMicrobialEnergeticsunderSteadyStateConditionsGrowthKineticsunderSteadyStateConditionsTheDilutionRateandtheGrowth-limitingSubstrateConcentrationBionmassandGrowth-limitingSubstrateConcentrationattheSteadyStateGrowthasaBalanceofFluxesTheFluxCoordinationHypothesisTowardaRationalDesignofCellsRedirectingCentralMetabolicPathwaysunderKineticorThermodynamicControlThermodynamicorKineticControlofFluxunderSteadyStateConditionsKineticandThermodynamicLimitationsinMicrobialSystems.CaseStudiesIncreasingCarbonFlowtoAromaticBiosynthesisinEschericahiacoliMethodsofQuantitationofCellular"ProcessesPerformance"StoichiometryofGrowth:TheEquivalencebetweenBiochemicalStoichiometriesandphysiologicalParametersAGeneralFormalismforMetabolicFluxAnalysisAComparisonbetweenDifferentMethodsofMFAMetabolicFluxesduringBalancedandSteadyStateGrowthBioenergeticandPhysiologicalStudiesinBatchandContinuousCultures.GeneticorEpigeneticRedirectionofMetabolicFluxMetabolicControlAnalysisControlandRegulationTheControlofMetabolitesConcentrationTheTDAApproachasAppliedtotheRationalDesignofMicroorganisms:IncreaseofEthanolProductioninYeastAppendixAAppendixBDynamicAspectsofBioprocessBehaviorTransientandOscillatoryStatesofContinuousCultureMathematicalModelBuildingTransientResponsesofMicrobialCulturestoPerturbationsoftheSteadyStateOscillatoryPhenomenainContinuousCulturesBioprocessDevelopmentwithPlantCellsMCEinPlants:RealitiesandPotentialitiesImprovingPlantsthroughGeneticEngineeringUsingPlantGeneticEngineeringtoProduceHeterologousProteinsToolsfortheManipulationandTransformationofPlantsPlantMetabolism:MatterandEnergyFlowsandtheProspectsofMCAMetabolicCompartmentationinPlantCellsCarbonAssimilation,PartitioningandAllocationCarbonfixationinhigherplantsMCAStudiesinPlantsRegulationandControl:StarchSynthesis,aCaseStudyConcludingRemarksCellularEngineeringOutlineTheGlobalFunctioningofMetabolicNetworksCellularEngineeringGrowthRate,G1PhaseoftheCellCycle,ProductionofMetabolitesandMacromoleculesasTargetsforCellularEngineeringCataboliteRepressionandCellCycleRegulationinYeastProteinProductionasaFunctionofGrowthRateTheSelectiveFunctioningofWholeMetabolicPathwaysisPermissiveforDifferentiationBibliographyIndex
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